| Player | Active | Position | Remark |
|---|---|---|---|
| Andre Onana | Start | Keeper | |
| Noussair Mazraoui | Start | Defender | |
| Matthijs de Ligt | Start | Defender | |
| Daley Blind | Start | Defender | |
| Nicolás Tagliafico | Start | Defender | |
| Lasse Schöne | Start | Midfielder | |
| Donny van de Beek | Start | Midfielder | |
| Frenkie de Jong | Start | Midfielder | |
| Hakim Ziyech | Start | Forward | |
| Kasper Dolberg | Start | Forward | |
| Dusan Tadic | Start | Forward | |
| Kostas Lamprou | Bench | ||
| Rasmus Nissen | Bench | ||
| Joël Veltman | Bench | ||
| David Neres | Bench | ||
| Klaas-Jan Huntelaar | Bench | ||
| Lisandro Magallán | Bench | ||
| Dani de Wit | Bench | ||
| Vaclav Cerny | Bench | ||
| Mitchell Bakker | Bench | ||
| Ryan Gravenberch | Bench | ||
| Jurgen Ekkelenkamp | Bench | ||
| Daley Sinkgraven | Bench |
| Player | Active | Remark |
|---|---|---|
| Hassane Bande | Injured |
| Sao Paulo | Minute | Ajax |
|---|---|---|
| First half | ||
| Goal Hernanes, after attack | Unknown | |
| Second half | ||
| 46 | Substistuted Nicolás Tagliafico out, in Rasmus Nissen | |
| 57 | Goal Donny van de Beek, assist: Rasmus Nissen, after attack | |
| 57 | Substistuted Donny van de Beek out, in David Neres | |
| Goal Brenner, after attack | 65 | |
| 72 | Goal Dusan Tadic, from penalty | |
| 78 | Goal Kasper Dolberg, assist: Dusan Tadic, after attack | |
| 81 | Substistuted Frenkie de Jong out, in Vaclav Cerny | |
| 81 | Substistuted Hakim Ziyech out, in Ryan Gravenberch | |
| 81 | Substistuted Kasper Dolberg out, in Jurgen Ekkelenkamp | |
| 81 | Substistuted Dusan Tadic out, in Lisandro Magallán | |
| 81 | Substistuted Lasse Schöne out, in Klaas-Jan Huntelaar | |
| 81 | Substistuted Noussair Mazraoui out, in Dani de Wit | |
| 90+1 | Goal David Neres, assist: Jurgen Ekkelenkamp, after attack |